Can cancer risk assessment models predict whether an individual woman will develop breast cancer? Dr. Pfeiffer: Women want to know: Will I get breast cancer? Unfortunately, these models cannot predict the future with certainty for any one individual. They present population averages. For example, if...

Researchers from the Wellcome Sanger Institute, The Institute of Cancer Research, London, and the University of Cambridge evaluated the health effects of genetic alterations in BAP1, a ‘tumour defence’ gene. They discovered that almost one-fth of these potential mutations were pathogenic...